More than 300 plants were found alongside growing equipment inside the building located in the town centre.
Officers were tipped off about the grow from a member of the public.
The force raided the premises on Saturday, May 8.
No one was present at the drugs factory, enquiries are now ongoing and anyone with information should contact West Midlands Police.
A spokeswoman for West Midlands Police said: “We recovered around 350 cannabis plants from a shop unit in Dudley town centre High Street on Saturday (8 May).
“They were discovered on the back of intelligence received from the public. No-one was in the unit at the time and our enquiries are continuing.
“Anyone with information is asked to contact us via live chat at www.west-midlands.police.uk 8am – midnight or call 101 anytime.
“To remain 100% anonymous please call Crimestoppers on 0800 555 111. Please quote crime number 20/425639/21.”